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The scandal from the Swamp: Too rich to get a cheap drug?
Poor countries all over the world are using Hydroxychloroquine (HCQ) and it appears to be very useful.
The new HCQTrial suggests that despite the billion dollar budgets and expert staff, people in wealthier countries are dying from Coronavirus at far higher rates than people are in lands where HCQ is being used. And the effect of HCQ apparently holds even after researchers correct for patients being older, heavier, with higher blood pressure, living in high density apartment towers, or with getting tested more.
If word ever gets out that the Politico-Academic-Corporate-Swamp buried useful drugs because they were unprofitable and out of patent, there will be hell to pay.
The HCQTrial was done anonymously by @CovidAnalysis — who say they are PhD researchers, scientists.
You can find our research in journals like Science and Nature. For examples of why we can’t be more specific search for “raoult death threats” or “simone gold fired”. We have little interest in adding to our publication lists, being in the news, or being on TV (we have done all of these things before but feel there are more important things in […]
Do 10,000 extra infections matter?
JoNova — cheaper and faster than a Parliamentary Report — said two months ago that it was baffling that the UK locked everyone down, but kept flying in the virus. Now British MP’s are saying the same.
UPDATE: Given Boris Johnson suddenly changed policy on flights from Spain last week, immediately adding a mandatory quarantine, what’s the bet someone told him this report was coming?
No 10’s ‘inexplicable’ decision to lift quarantine at height of pandemic: MPs’ damning report condemns ‘serious mistake’ that allowed 10,000 infected people into the UK
David Barett, DailyMail
Delaying quarantine measures at the border was a ‘serious mistake’ that allowed 10,000 infected people into the UK accelerated the virus spread, a major report by MPs says.
The cross-party inquiry is highly critical of the Government’s ‘inexplicable’ decision to lift its initial quarantine measures in mid-March, ten days before lockdown.
Experts from the London School of Hygiene and Tropical Medicine calculated that up to 10,000 infected people, largely from Spain, France and Italy, imported the virus into the UK.
Viruses can only survive in people temporarily, so to beat a rogue chemical […]
A telling incident in Western democracies about borders
The electoral power of strong borders is vastly underestimated.
Western Australia has hard borders at the moment, and no coronavirus — other than a few cases getting caught in the mandatory quarantine. That’s 2.5 million people who are almost living a normal life. This is not to boast (we wish you could be here), but to point out how politically popular closed borders are in the current pandemic. The Premier is wildly popular, polling close to 90%. To all the people who said “states can’t close borders” the message is that it’s bonkers not to close borders. When the Commonwealth government joined the bizarre High Court push to force them open, the pushback was ferocious. A poll today showed that West Australians are fed up. The West Australian collected 245,000 signatories to a petition supporting the border closure.
Not only do 96% say the borders should stay shut, but when asked, a whopping 34% of Western Australians said the state should secede. How fast did it come to that?
Never, have I seen such vitriol towards the Commonwealth from WA. …the Commonwealth’s decision to effectively join hands with […]
No wonder the Chinese lockdown a million people with every outbreak. Two thirds of these cases were not hospitalized.
These studies are small and need confirmation, but the medical specialists are asking if it is possible that Covid infections create new cases of heart failure which may trigger problems long after infection?
A startling number of COVID-19 patients suffer lasting heart damage
Fermin Koop, ZME Science
A study from the University Hospital Frankfurt looked at the cardiovascular MRIs of 100 people who had recovered from the coronavirus and compared them with heart images of people who hadn’t been infected.
Most of the patients hadn’t been hospitalized and recovered at home, with symptoms ranging from none to moderate. Two months after recovering from COVID-19, the patients were more likely to have troubling cardiac signs than people in the control group. Up to 78% of them had structural changes to the heart, while 76% had evidence of a biomarker signaling cardiac injury typically found after a heart attack, and 60% had signs of inflammation.
The Puntmann study was based in Germany, and the average age of cases was 49. Troponin is a marker used in standard […]
New research shows that families with teenage children were three times more likely to get Covid (odds of spread , 18%) than families with children under ten (5%). It appears that it’s more dangerous to live with teens than to live with adults (12%). It may be that teens are more likely to be asymptomatic which means people don’t realize they need to isolate from them.
The question of opening primary schools is potentially very different to high schools. Quite possibly puberty affects immune systems in ways that make teens effectively young adults.
Older Kids May Transmit COVID-19 as Much as Adults Do, New Evidence Shows
ScienceAlert
The results also showed up something unexpected, however. When index patients were categorised by age (0–9, 10–19, 20–29, 30–39, 40–49, 50–59, 60–69, 70–79, and >80 years), households with older children (index patients of 10–19 years) had the highest rate of infection spread to household contacts, with 18.6 percent of household contacts later showing the infection.
By contrast, young children (index patients 0–9 years of age) seemed to confer the least amount of spread of the virus, with just 5.3 percent of household contacts contracting the infection, which […]
Antibody tests versus PCR tests: PCR tests are nose or throat swabs that amplify up short fragments of viral RNA. They only detect infection in the day or two before symptoms show, and for a few days to a few weeks later. The PCR tests cannot show past infections. Antibodies take around a week or two to rise so don’t show active infections, but will show up past ones, though — in the case of Coronavirus, may still produce no result after a few months in some people as antibodies decline.
Test results like these must finally have convinced Donald Trump to change course. It’s long past time the US got serious about this disease, but hopefully rapid action now — masks and distancing and more testing can prevent the trainwreck of rapidly rising infections across the US in two months time as winter and the US election approach.
This study shows that most people in the US have not had this virus, and herd immunity is unattainable without hundreds of thousands more deaths. It also shows how inadequate testing is in the US.
Many antibody studies have tried to estimate the true extent of the Coronavirus infection. Some were […]
Welcome to the Era of the Anti-Virals. They’re everywhere.
A legacy of the coronavirus pandemic is the dawn of new ways to stop viruses. Here’s another new (old) one — it’s only a small trial, but if it can stop 4 out of 5 people developing the severe form of the disease it will be a gamechanger. If this gets similar numbers on larger trials, then we still need mass production. But national policies will swing on a dime if a safe drug with this much potential appears.
After Coronavirus we might not be so content to accept the annual seasonal virus scourge.
Postenote: These are preliminary results, not a large trial, but at least it is placebo controlled and randomized.
Breakthrough’ treatment slashes virus death risk: study
by Patrick Galey, MedicalXpress
In a randomised trial of 100 patients admitted to hospital with COVID-19, those who received an inhaled formula of the protein interferon beta were at 79 percent lower risk of developing severe disease compared to those who received a placebo.
They were also more than twice as likely to make a full recovery compared with the control group.
The firm […]
It says something about the mortality rate of Covid19, and also about the burden on the healthcare sector
According to the CDC, there have been 103,643 cases of Covid-19 in US Healthcare workers of which 543 have died. That makes the death rate per infection a hefty 0.5% among these working age people. Obviously some of these people have co-morbidities, but would be under the retirement age.
We would hope US Healthcare workers are reasonably well tested. They may have a higher death rate because they are subject to a higher viral load and working under long hours in a stressful situation. But they also (presumably) wear PPE and are trained to use it.
An Amnesty International report estimates at least 3,000 health care workers have passed away around the world, with the highest tally from Russia (545) and the UK (540).
Elsewhere, the countries with the highest numbers of health worker deaths are USA (507), Brazil (351), Mexico (248), Italy (188), Egypt (111), Iran (91), Ecuador (82) and Spain (63).
These numbers may be underestimates. The Guardian has a list of US Health care worker deaths, and lists the names 787 frontline workers.
Medscape has a […]
Scott Morrison says eliminating the virus is not viable, despite most states in Australia effectively managing to do that already. See the chart below. Instead he talks of suppression as if it’s viable to ride an exponential curve with a default position of “moonshot”.
At the start of June, Victoria was getting 20 new cases a week. In the last three weeks Victoria has added 3,000 cases.
State premiers are being urged to reject an elimination strategy for coronavirus, with Scott Morrison and leading business groups warning the move would double unemployment and wreck the economy.
The Prime Minister, who has conceded the lockdown of Greater Melbourne was necessary given the size of the outbreaks, warned that any pivot to an elimination strategy would double unemployment.
Suppression sounds like a management plan but means rolling waves of infection and isolation, with outbreaks of chaos and a constant higher level of fear and avoidance. This does not seem like a jobs creation machine.
Would we prefer one lockdown or three?
1. The hospitalization rate means hospitals will be overwhelmed within weeks (see Victoria). Therefore repeat lockdowns are inevitable.
2. It’s hard to protect […]
If only they had done that 3 months ago
As I predicted, borders need to close. Places that don’t close the state border end up putting a border around every single home. It’s the same all over the world. But no one seems to have noticed how spectacular this backflip is.
In March when New York was the epicentre begging for ventilators, Donald Trump suggested quarantining the tri-state area to stop infections spreading to the rest of the US. It was exactly the right thing to do, but Governor Cuomo was enraged — declaring the idea was “preposterous”, “anti-American” and a “declaration of war”. Cuomo even argued it would be illegal for Trump to do so, and threatened to sue:
“I’ve sued the federal government a number of times over the years. I do not believe it’s going to come to that on this,” Cuomo said. “This would be a declaration of war on states, a federal declaration of war.“
Right now there are 22 US states which could threaten to sue Cuomo for the infections New Yorkers gave them.
It was weapons grade bluster on March 28, 2020, but which media outlets and creatures from the Swamp […]
Mass gatherings linked to mass outbreaks. Who could have seen that coming?
But many details are missing or unknown. They’re not saying that the protest caused the megacluster, or whether the protestors live in the towers, or whether the virus spread from the family outbreak to the tower or the other way.
We do know that four weeks after the BLM rally the state was in deep trouble.
Coronavirus: Black Lives Matter protest linked to tower cluster
Rachel Baxendale, The Australian
Victorian health authorities have confirmed a link between two COVID-19 cases in people who attended the Black Lives Matter protest in Melbourne’s CBD just over a month ago, and the cluster of at least 242 cases in public housing towers in the city’s inner northwest.
But the Department of Health and Human Services has refused to say whether members of the cluster, which includes the protest attendees, live in the public housing towers.
One H&M worker was at the rally and later tested positive and that three other H&M workers eventually tested positive. The H&M cluster become “North Melbourne family cluster” which grew to 30 cases. Three weeks after the rally the North […]
It’s a molecular monster
The SARS-Cov2 virus can take over and does some pretty cool engineering. (At least in the case of monkey cells.)
The infected cells produce hairy tentacles that poke holes in nearby cells to help spread the virus.
Coronavirus tentacles with small yellow virus particles attached.
So once a virus is inside it can not only hijack the cell to make more viruses (the little yellow prickly balls in the photo) it also forces the cell to make all these hairy tentacles to push the viruses into neighboring cells. Apart from being a neat gee-whiz moment in molecular construction, this is worth knowing because it gives us more targets to aim for. (More moving parts to throw spanners at).
To that end, the team found 87 drugs that are already either FDA approved or in clinical trials that might help. And 7 of them have already shown they can inhibit the virus in both human and monkey cells.
There are some major molecular engineering battles going on
Coronaviruses are larger RNA viruses than most, so that gives the virus more tools to work with. All up we know that there are 27 SARS Cov2 proteins which […]
Coronavirus may leave a trail of benefits in its wake. Who knew that there were so many cheap antivirals around? Will people get fed up with the limited choices on offer next time there is a quarantine.
While newspapers in Australia were pretty keen to share the discovery of an antiviral role for HCQ, not so many were interested in the followup studies.
Ivermectin, like hydroxychloroquine is a kind of superdrug — in the sense of being in worldwide mass use. Some 3.7 billion doses are estimated to have been given since its approval. It has been called the Japanese Wonder Drug. It’s the farm drench, a head lice treatment, and works against worm, mites and ticks too.
It was estimated to reduce viral loads in vitro massively but most people didn’t think it would work at lower safe doses. Then Bangladeshi doctors claim it was “astounding”. Last month US tests suggest that it reduced deaths by 40%. (Rajter)
These are all every priminary results. More studies are promised for Ivermectin. Especially in Peru, where a grassroots movement of Doctors has ensured it will be used.
A US clinical trial of the drug ivermectin found that it reduced […]
The whole of Melbourne is now in a six week lockdown again, but thankfully, most of regional Victoria isn’t. The freedom in regional Victoria is solely due to a “ring” around Melbourne.
Not only is the second peak bigger than the first one, but it’s all community spread this time. Fully 191 new cases of Covid19 were announced in Victoria today. Ominously, only 37 so far can be traced (so far), which means this is not just about spot testing in the nine high rise towers that are now locked down. So , no indoor sport, no gyms, or concerts, museums or zoos can open. No more dining in restaurants and given the disturbing number associated with schools, the start of Term 3 has been delayed by a week for years 1 – 10, and possibly longer. But fishing, boating, golf, and surfing are OK. It’s good to see the quarantines are evolving, recognising the minimal benefit of stopping dispersed outdoor activity.
For people overseas, the Australian style of lockdown permits people to move for work if they can’t stay home, and to shop for essentials and to exercise. Jobs are considered essential, but people are encouraged to work […]
One good thing about Coronavirus is that people are suddenly paying attention to all the cheap easy ways to slow viruses. Hopefully we will get a bit better at preventing other respiratory infections too.
As I’ve mentioned before, masks stop as much as 75% of influenza, and now we know the number is similar with Coronavirus. If any drug was this effective, it would be hailed as a Gamechanging Breakthrough (!).
Indeed, just yesterday Anthony Fauci said he’d settle for 70%, 75% effective vaccine, but masks are here already. And we don’t have to wear them forever, just til we starve the virus, set up border checks, and get the cases to zero. Then we wait for a long term solution. 2020 is going to be the year of the mask.
With Coronavirus cases ramping up again all over the world, people like Mike Pence, and Australia’s Health Minister are talking about them. If we add Vitamin D at 5c a dose (which can reduce the spread of influenza by 40%) perhaps some states could avoid a repeat mass lockdown?
Given the cost in deaths and dollars of the spread of this virus, it would be cheaper to […]
As lockdown restrictions are released, and social distancing is blown away by riots and rallies, the virus is coming back in some parts.
Victoria gets 25 new cases, cancels “reboot” and ramps up restrictions again
Two weeks after restrictions were partially released and the BLM rallies took place in Melbourne, the surge comes. Actual spread at the BLM rallies is hard to pin down but the rank hypocrisy that allowed the rallies to take place skewered the community commitment to social distancing. With thousands congregating, almost entirely without fines and in breach of the rules, no wonder family gatherings grew. People had given up so much during the lockdown, but indulgent rally organizers could not delay the rallies by another month, or shift them to an online form.
Among a new string of coronavirus cases in Victoria are people who knew they were infected but continued to work and socialise anyway, Premier Daniel Andrews has revealed. The state will reintroduce restrictions after recording another 25 new coronavirus cases in the past day, with concerns that a second wave of COVID-19 is possible.
Blaming families seems a bit rich given the flagrant disregard shown by protestors and the politicians, […]
Results from China, Japan, and USA show that half or more of asymptomatic cases have lung damage
Asymptomatic cases show a weaker immune response. In a small study in China, the asymptomatic cases had a lower, slower immune response, which means they shed virus for longer than the symptomatic cases, perhaps even as long as 14 days. Though the presence of viral RNA does not necessarily mean they can infect other people. It may be fragments of the whole virus.
a, CT scan of a 45-year-old female showing focal ground-glass opacities in the lower lobe of the left lung (arrow). b, CT scan of a 50-year-old female showing ground-glass opacities and stripes coexisting in the lower lobe of the right lung (arrows).
Below, a Scripps review found the rate of lung damage was as high as 70% of asymptomatic cases. Both these studies are small, non randomized, retrospective studies.
It’s not surprising that people might not notice that their lungs were underperfoming. We have so much extra lung capacity for day to day living that many people don’t notice damage. In cases of lung cancer, people are often not diagnosed until they are in an advanced late stage. Presumably, […]
The most popular drug with doctors all over the world will seemingly now not even be allowed in the US for Covid related treatment: HCQ No Longer Approved Even a Little for COVID-19
Molly Walker, MedPage
The FDA rescinded its emergency use authorization (EUA) of hydroxychloroquine (HCQ) to treat COVID-19 patients, citing concerns about efficacy and risks associated with its use, and saying the drug no longer meets the criteria for an EUA, the agency said on Monday.
Moreover, the FDA now says the benefits of the drug “no longer outweigh the potential risks,” citing the serious cardiac adverse events associated with the drug.
Comments underneath reveal just how contested this will be.
It’s a strange situation where patients in many poorer nations are being offered drugs that patients won’t be able to get in the richest nation in the world:
Substantial fractions of physicians treating Covid-19 patients in Europe and elsewhere report use of HCQ+AZ: 72% in Spain, 49% in Italy, 41% in Brazil, 39% in Mexico, 28% in France, 23% in the US, 17% in Germany, 16% in Canada, 13% in the UK (45), much of the non-US use […]
Watching the photos and twitter feed from China it was obvious something terrible was happening and the official numbers did not add up.
For example, there were reportedly 90,000 hospital beds in Wuhan in 2018, yet another 100,000 beds were suddenly urgently added in schools, hotels, and pop-up new hospitals, even though there were only 30,000 official cases. Some 169,000 ventilators were supplied to Wuhan, which was inexplicable if there were only 50,000 total cases during the whole pandemic.
Remember on February 6th when keen observers noticed that the Tencent Virus tally board had been flickering with a ghostly alternate count that was ten times higher than official numbers (and 80 times higher in deaths). We wondered if someone was trying to leak out the real situation.
The official statistics:
The official Coronavirus count in China Image by Pheonix7777
Three months after all these discrepancies, CNN, BBC and co. would still be treating Chinese figures like they meant something. Most media institutions were reporting meaningless “sombre moments” as one country after another overtook a mythical Chinese data point. “Italy has overtaken China”, Spain has…. None of the news giants looked further or even said “alleged figures”.
The new study […]
Fascinating. Could one shot of radiation calm Covid infected lungs and stop the severe cytokine storm?
In a trial in the US, five very sick Covid patients with a median age of 90 were given a “low dose” (which is not so low) of 1.5 Grey (150 Rad) of Photon beam radiotherapy (in a front and back beam configuration.) It took only 10 – 15 minutes, and four of the five showed “rapid improvement” in 24 hours. Their oxygen levels and alertness improved. They were sent home from hospital 12 days later.
The good thing about this is that apparently most hospitals already have this equipment, so they could start helping people right away (assuming it works, which we don’t know yet).
Radiation isn’t anti-viral, it’s anti-inflammatory
In theory, the shot of radiation is not “killing the virus” but is changing the immune response — and may be able to stop the deadly cascade of the cytokine storm. It calms the immune system in at least three ways (see the chart).
Anti-inflammatory treatment for Covid-19.
The curious thing about this is that it is an old treatment, and an old idea. “Hormesis” is a phenomenon where low grade […]
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