JoNova

A science presenter, writer, speaker & former TV host; author of The Skeptic's Handbook (over 200,000 copies distributed & available in 15 languages).


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Hydroxychloroquine, a year later, 3 times higher survival rate. Trump was right.

Photo: Whispyhistory

The world faced the greatest global health crisis in one hundred years, but it’s taken a whole year to write up a small study that shows hydroxychoroquine could improve the survival rate of people on ventilators by a factor of three, and that the dose matters.

If anyone says “but this is not a big study”, that’s exactly my point. Why is it so hard to get a large study of a drug that was already known to be useful against SARS-1 fifteen years before SARS-2 arrived. A drug that even the President of the US was talking about in the earliest days? In January 2020 we already knew that the three drugs that were “fairly effective” were Remdesivir, Chloroquine and Ritonavir. On February 13, the South Koreans were already recommending hydroxychloroquine and telling us the anti-virals should be “started as soon as possible”. We had that head start, we threw it away.

Apparently the kings-of-compassion in the commentariat would rather see deaths than admit Donald Trump was right. And the experts in Pharmaceutical Giants only cared about the profit line.

And so it comes to pass, finally, that we find out what happened to 255 […]

It’s the biggest medical scandal since 1850 — there are even claims the US President was treated in secret

History books will be written and some professors, academics, and bureaucrats will have no excuse.

Which organisations can serve now?

It took two court hearings and major complaints and assertive activism to save eighty year old Judy Smentkiewicz. But how many others died because their sons or daughters didn’t see Pierre Kory on TV? Or they didn’t have the wherewithal to go to court? Or their friends trying to share the message were censored on Facebook? It shouldn’t have to be this way.

This is Judy’s story below, but so much more. Read the whole thing. It’s very well written by Michael Capuzzo. Surely, this is a story that needs an answer. Where are the Forth Estate, the Opposition, The AMA, or the publicly funded professors at our universities?

I am but a cog passing on points of view that should be part of our national conversation. Some things matter: like antivirals and closed borders.

Nick Corbishley says “I don’t know of a bigger story in the world”

Michael Capuzzo, a New York Times best-selling author , has just published an article titled “The Drug That Cracked Covid”. … But unfortunately most reporters are not […]

Has Israel found the cure for Covid?

Just another anti-viral

There was a good but small (tiny) study that came out of Israel three weeks ago about a drug called EXO-CD24. The professor in charge claims to have treated 30 out of 30 people who had moderate to severe cases and had near universal success. All, bar one, were able to leave hospital very quickly. CD24 is normally stuck on the outside of immune system cells. By getting EXO-CD in, apparently they can stop the cytokine storm.

Any day now, the mainstream media will let us know. The media may also mention that unlike vaccines the drug EXO-CD24 and according to Professor Nadir Arber, could be scaled up and mass produced within a few months and they could provide enough doses for the World.

Has Israel found the cure for Covid?

“To date, the preparation has been tried with great success on 30 severe patients, in 29 of whom the medical condition improved within two to three days and most of them were discharged home within three to five days. The 30th patient also recovered but after a longer time,” the hospital reports.

“The drug is based on exosomes, [vesicles] that […]

Asthma drug Budesonide reduces Covid hospitalization rate dramatically

The STOIC study gave an asthma drug to Covid patients, but it worked so astonishingly well, they had to stop the trial early, as it was unfair to keep giving the placebo to people who were ending up in hospital ten times as often as people who got Budesonide.

“We were hoping for 50% reduction [in severity]. We got 90%, which … is off the charts”

–h/t Eric W at WUWT

Though to keep some perspective, out of about 140 people enrolled, 70 got the drug and 70 got the placebo, with 10 of the placebo group going to hospital and only 1 in the Budesonide group.

You’ll be shocked to know that giving the drug early works better than waiting for the virus to replicate wildly. You’ll also be shocked that there were some doctors using this 7 or more months ago, and yet the media didn’t mention it Apart from Newsmax. (Eg See Dr Richard Bartlett talk about this back in July last year, who talks of using a nebulizer, not an inhaler. )

Common asthma drug slashes Covid hospitalisation by 90%, experts say

Vanessa Chambers, The Sun

A […]

In Peru, Ivermectin cut covid deaths by 75% in 6 weeks: cheap, safe and quite ignored

How many unnecessary deaths does it take til people get angry? Angry that the Chief Medical Officers and Health Ministers didn’t ask for studies to be done. Angry that most academics sat by and said nothing. And angry that the media just parroted the institutions.

One good antiviral changes everything. If the world had a safe cheap drug, we could not only reduce deaths and disability, but also slow the rate of mutation down and probably slow the appearance of new mutations down.

The Chamie-Quintero study from Peru shows the West could be only weeks away from reducing the Covid death toll if we used the safe cheap sheep-dip, lice-killing Ivermectin like less wealthy countries do.

A study across the states of Peru found that after Ivermectin was introduced, deaths started to fall about 11 days later, and within a month after that, deaths were down around 75%.

Ivermectin is a drug so useful early researchers got a Nobel Prize in Medicine for work on it. It’s so well known that in the last thirty years more than 3.7 billion doses of Ivermectin have been given out. It’s so safe we can use it on cats […]

Covid tricks — spikes block pain pathway — hiding the infection

Another day in the strange world of Covid

A new finding suggests Covid-19 doesn’t just bind to the ACE2 receptor, it also binds to a key pain receptor called neuropilin-1 receptor (NRP-1). This could explain why some people with a high viral load are asymptomatic and infectious but unaware they are unwell. It’s like the virus is arriving with it’s own morphine. In theory this might be a successful adaption from the virus’s point of view as it may increase the spread of the disease if infected people wander around able to shed virus for longer.

Despite being fed up with the WuFlu, the efficient perfidy is something to behold (at least to a microbiologist). It’s like a pocketknife.

On the down side, the virus may still be damaging tissues in this painless state, which might explain some of those findings of lung and heart damage even in mild or asymptomatic cases.

There is at least one potentially very nice payoff. The finding from the University of Arizona, may lead to the design of whole new painkillers based on the coronavirus spike that is “better than opioids”. The lead author says he has been contacted by people who had […]

Vitamin D reduced the rate of ICU admission from 50% to 2%. Do black lives matter?

Given that people with dark skin are more likely to be deficient in Vitamin D, wouldn’t studies like these be the best way to show that black lives actually matter? Would you like training in cultural sensitivity or to avoid the intensive care unit?

A free antiviral shining down on you?

In the Castillo study in Spain, 76 patients were randomly assorted into Calciferol treatment ( 0.532 mg Vitamin D ). Of the 26 who didn’t get it, 13 were admitted to the ICU. Of the 50 who got Vitamin D doses on days 1, 3, and 7 — only one ended up in the ICU. It’s worth noting that all patients got HCQ as well, and azithromycin too.

A second study tested 500 people to find out if they were deficient and followed them to see if they caught Covid.

Why has it taken 6 months of pandemic to do these small studies?

Before the pandemic came there was already ample evidence suggesting that it mattered. Vitamin D influences over 200 genes. Its levels also correlate with lower rates of cancer, diabetes, high blood pressure, asthma, heart disease, dental caries, preeclampsia, autoimmune disease, depression, anxiety, and sleep disorders. […]

Even cough syrup might actually work against Coronavirus

I didn’t think cough syrups even worked against coughs, but one new paper suggests that bromhexine in common cough syrups reduces both Covid-19 rates of ICU and of mortality.

The era of antivirals has come, not that Big Pharma want you to know that cheap out-of-patent drugs might help. But for years we were told that medical science didn’t have an answer to viruses.

Bromhexine was patented in 1961 and is commonly found in OTC pharmacy cough syrups with names like Bisolvon, Robitussin, and Duro-Tuss (Wiki has a long list).

Theoretically Bromhexine sabotages one of our molecules — with the snappy name of TMPRSS2 (which is shorter than saying Transmembrane protease S2). A protease is a fancy pair of molecular scissors, it chops or tweaks the viral spike and if that doesn’t happen, the virus can’t get into the cell (at least not through its favourite path).

The nice thing about an antiviral acting against our molecules, rather than against the virus itself, is that it’s harder for the virus to mutate to get around it. That means it’s less likely the virus can develop resistance. The downside of targeting our own molecules is that it might fritz things up. […]

More cheap potential Covid treatments, Ivermectin saves 50%

Coronavirus may leave a trail of benefits in its wake. Who knew that there were so many cheap antivirals around? Will people get fed up with the limited choices on offer next time there is a quarantine.

While newspapers in Australia were pretty keen to share the discovery of an antiviral role for HCQ, not so many were interested in the followup studies.

Ivermectin, like hydroxychloroquine is a kind of superdrug — in the sense of being in worldwide mass use. Some 3.7 billion doses are estimated to have been given since its approval. It has been called the Japanese Wonder Drug. It’s the farm drench, a head lice treatment, and works against worm, mites and ticks too.

It was estimated to reduce viral loads in vitro massively but most people didn’t think it would work at lower safe doses. Then Bangladeshi doctors claim it was “astounding”. Last month US tests suggest that it reduced deaths by 40%. (Rajter)

These are all every priminary results. More studies are promised for Ivermectin. Especially in Peru, where a grassroots movement of Doctors has ensured it will be used.

A US clinical trial of the drug ivermectin found that it reduced […]

Hydroxycholoroquine *may* save half the people who were going to die of Covid

Good news on the HCQ front

The Henry Ford HCQ study is by no means decisive, but with death rates seemingly halved (sorta, maybe, kinda) — it does show how crazy it is to ban hydroxychloroquine. It also shows it’s low risk, and with all the conflicting studies out there, that there are a lot of ways to stuff things up.

With 10 million cases around the world it seems a bit incongruous that it’s taken so many months to get a trial this basic done with 2,000 patients. When the world only had 10,000 patients in January we already knew that the three drugs that were “fairly effective” were Remdesivir, Chloroquine and Ritonavir. As far back as February 13, the South Koreans were already recommending hydroxychloroquine and telling us the anti-virals should be “started as soon as possible.” They warned that after ten days, doctors “do not have to start antivirals”. South Korea was the experiment that worked — but we ignored it.

Speaking of slow research, the UK hydroxychloroquine trial that was stopped has restarted again as of three days ago. This is a trial to see if HCQ can prevent coronavirus in 40,000 healthcare workers.

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