JoNova

A science presenter, writer, speaker & former TV host; author of The Skeptic's Handbook (over 200,000 copies distributed & available in 15 languages).


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Ivermectin may prevent 86% of Covid cases, and the UK will do a hobbled trial of it

The new super meta review of Ivermectin is out. It’s 27 pages of fine print detail and 144 references, and it’s very impressive.

Ivermectin…. by Fvasconcellos

Bryant et al soaked themselves in 24 studies involving 3,406 people and found that ivermectin use reduced deaths by a very nice 60% with “moderate certainty”. But ivermectin appears to be at its best when used to prevent infections in the first place. There was “low certainty” but with prophylactic use Covid infections were reduced by an average of 86% . But by the time patients were “in need of mechanical ventilation”, the data, while muddy, suggested ivermectin was not much help.

The bad thing about Ivermectin is that there are not many bad things. It’s too good, too cheap, too safe, and too far out of patent to be profitable.

Given the evidence of efficacy, safety, low cost, and current death rates, ivermectin is likely to have an impact on health and economic outcomes of the pandemic across many countries. Ivermectin is not a new and experimental drug with an unknown safety profile. It is a WHO “Essential Medicine” already used in several different indications, in colossal cumulative volumes.

[…]

Indias Health dept stops Ivermectin use but others sue the WHO

The good news is that there is a way out of the new mutant load. The bad news is the Swamp is in the way.

India’s caseload has continued to shrink since we last looked at it. Which is great news, but instead of endorsing the approach that worked, the health ministry is now writing to doctors telling them not to use Ivermectin and Hydroxychloroquine.

Indeed the new recommendations even go so far as to say that zinc and multivitamins are out too. Even zinc?

Ponder that Ivermectin is so powerful it even destroys multivitamins.

Is the day coming when we see antivirals suddenly accepted like the Wuhan Lab theory was? Lives depend on it, but vast piles of money do too. The medical censorship swamp is well equipped, and I suspect, has years of experience. There are so many anti-viral medicines, they’ve been around for years and all the financial incentives not to use cheap out-of-patent drugs have always been there.

Here are the graphs of infections in some states of India:

So who leaned on the Indian officials? Who knows?

Ivermectin, Doxycycline Dropped From List of COVID-19 Drugs by Health Ministry

New Delhi: […]

A cloud of Covid variants circles the globe

Mutations of SARS2 are roaming. Currently there are 19 million active (known) cases of Covid. Due to copying errors, mistakes are accumulating in the genes of the virus. It’s a relentless process of trial and selection. A trillion monkeys on keyboards blindly working its way around vaccines, and immune systems. To beat this, we need to understand it.

Below is a map of known variants created from the samples which have had full sequences done. This is the remarkable “Nextstrain“ — an opensource tool. I have labelled a few clusters by their “country names”, (though we’re not supposed to do that. Let’s all say “WuFlu”.)

The family tree of SARS-Cov-2 starts at the bottom left corner with two samples from Wuhan around Christmas 2019. This is called the 19A clade, which appears to have almost died out now, though there are still remnants left of this original virus in corners like Iran and PNG. Otherwise, the Wuhan 19A virus has been superseded by its children.

The branches and time marches to the right.

Nextstrain: Latest global SARS-CoV-2 analysis

The code for one full virus is 29,000 bases long and as best as I can tell, all the dots […]

Summer deaths: How to ignore most variables and a great trend and still blame climate change

This might be one of the most incompetent studies of 2o21

Hanigan, Dear and Woodward have done a “unique”, first of, *groundbreaking study* that finally shows climate change is having a detrimental effect on our health (so they say). With great effort to ignore almost every variable that mattered, they found the seasonal ratio of deaths in Australia has changed:

”More people die in winter than summer, but climate change may see this reverse

In our study published today, we show some of the first evidence climate change has had observable impacts on Australians’ health between 1968 and 2018.

We found long-term heating is associated with changed seasonal balance of deaths in Australia, with relatively more deaths in summer months and relatively fewer deaths in winter months over recent decades.

Our findings can be explained by the gradual global warming associated with climate change. Over the 51 years of our study, annual average temperatures increased by more than 1°C in Australia. The last decade (2011 to 2020) was the hottest in the country’s recorded history.

The other interpretation is that it got warmer and deaths in winter declined more than deaths in […]

Covid: Biggest risk factor is not being fat or diabetic — but sitting still

Could we halve the death rate if we just exercised 25 minutes each day?

..

A lot of people were asked how much they exercised a couple of years ago. In follow up, about 50,000 went on to catch Covid last year. They were sorted into three levels of exercisers — the 7% most active consistently got 150 mins of week of something akin to “brisk walking” or more. The slowest moving 15% qualified as true couch potatoes — doing less than 10 minutes of exercise a week.

Sadly for the least active, they were 2.3 times more likely to need to go to hospital, 1.7 times more likely to be sent to the ICU and 2.5 times more likely to end up in the morgue.

These are pretty stark figures — making sedentary behaviour more risky than obesity, smoking, diabetes and high blood pressure. Which all seems a bit surprising given how many hours of data collection and TV commentary has been spent on all the smaller risks. How did we manage to miss one of the most important variables there is?

Exercise is “one heck of an anti-viral”

If these results are correct, it suggests most […]

Vitamin B6 may reduce the cytokine storms of Covid

Maybe getting enough Vitamin B6 will reduce deaths

The main two things that kill people with Covid are blood clotting and an out-of-control inflammation known as a cytokine storm. A group of researchers noticed that both of these were things Vitamin B6 was known to reduce — blood clotting, and inflammation. In particular, there’s a molecule called Interleukin 6 which is a “masterplayer” signal in our immune system and — what do you know — B6 reduces it. Mice that weren’t fed enough B6 got mouse pneumonia more than mice who were fed enough. B6 is anti-inflammatory, anti- and reduces reactive oxygen species (ROS).

The Big Black hole in medical research?

I hoped this paper was report on experiments with Covid patients, but the paper and press release is essentially a literature review of many pre-covid studies and a plea for research into whether vitamin B6 might help stop the deadly cytokine storm.

The bigger, global question they don’t ask, is why despite the millions (billions) going into vaccine design and drug research, hardly anyone is studying the cheap unprofitable and obvious questions? Perhaps we need some government funded research that’s not driven by profits… oh. wait.? What happened to […]

Asthma drug Budesonide reduces Covid hospitalization rate dramatically

The STOIC study gave an asthma drug to Covid patients, but it worked so astonishingly well, they had to stop the trial early, as it was unfair to keep giving the placebo to people who were ending up in hospital ten times as often as people who got Budesonide.

“We were hoping for 50% reduction [in severity]. We got 90%, which … is off the charts”

–h/t Eric W at WUWT

Though to keep some perspective, out of about 140 people enrolled, 70 got the drug and 70 got the placebo, with 10 of the placebo group going to hospital and only 1 in the Budesonide group.

You’ll be shocked to know that giving the drug early works better than waiting for the virus to replicate wildly. You’ll also be shocked that there were some doctors using this 7 or more months ago, and yet the media didn’t mention it Apart from Newsmax. (Eg See Dr Richard Bartlett talk about this back in July last year, who talks of using a nebulizer, not an inhaler. )

Common asthma drug slashes Covid hospitalisation by 90%, experts say

Vanessa Chambers, The Sun

A […]

In Peru, Ivermectin cut covid deaths by 75% in 6 weeks: cheap, safe and quite ignored

How many unnecessary deaths does it take til people get angry? Angry that the Chief Medical Officers and Health Ministers didn’t ask for studies to be done. Angry that most academics sat by and said nothing. And angry that the media just parroted the institutions.

One good antiviral changes everything. If the world had a safe cheap drug, we could not only reduce deaths and disability, but also slow the rate of mutation down and probably slow the appearance of new mutations down.

The Chamie-Quintero study from Peru shows the West could be only weeks away from reducing the Covid death toll if we used the safe cheap sheep-dip, lice-killing Ivermectin like less wealthy countries do.

A study across the states of Peru found that after Ivermectin was introduced, deaths started to fall about 11 days later, and within a month after that, deaths were down around 75%.

Ivermectin is a drug so useful early researchers got a Nobel Prize in Medicine for work on it. It’s so well known that in the last thirty years more than 3.7 billion doses of Ivermectin have been given out. It’s so safe we can use it on cats […]

Paralyzed mice walk again after just a few weeks

We all could use some good news, and this is quite extraordinary.

“Using gene therapy, a research team has succeeded in getting mice to walk again after a complete cross-sectional injury. The nerve cells produced the curative protein themselves.”

The Town Mouse and The Country Mouse both like this news. | Illustrated by Milo Winter

Normally spinal cord damage is pretty much permanent. Even though we all still have the same genes that built the nerves in the first place, no one seemed to have the right reboot code that could switch on the correct genes in the right order to do the repair. And to give you some idea of the complexity of this, in 2018 a different team estimated that as many as 580 genes may be involved in axon regeneration.

Plenty of researchers have been tapping on the windows and doors of the Nerve Regrowth Holy Grail. This time, instead of just regenerating a nerve in a petri dish, or even even a live animal, they’ve gone a leap further. These mice could walk again.

And all it took was a single injection? “This was a great surprise to the researchers”.

Junk study on Vitamin D shows nothing much but how bad science reporting is

The Sunlight Vitamin

UPDATED! Mea Culpa from me. The post has been corrected*. Thanks to Rob.

__________________

More junk reporting from the Australian government broadcaster the ABC which just copies the junk science press release. Is this what we pay $1b a year for?

The Journalists missed the key factor which was blood levels of participants.

The headline says Clinical trial finds vitamin D does not ward off colds and flu but all it really shows is that in a group that already have *normal, non-deficient levels* of Vitamin D, taking big doses of Vitamin D once a month won’t will raise your blood levels — but won’t make a big difference to your risk of respiratory infections. And it only applies to people aged 60 -74.

Most participants in the study had a normal but sub-optimal Vit D levels and after five years of sporadic high doses, were raised to optimal levels at the end.

After taking 60,000 IU each month, supplementers apparently went from having 77.5 nmol/L up to 114.8 nmol/L,. To put this in perspective, normal levels of Vitamin D start at “50” and above, and there are professors who point out that there are […]