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Another day in the strange world of Covid
A new finding suggests Covid-19 doesn’t just bind to the ACE2 receptor, it also binds to a key pain receptor called neuropilin-1 receptor (NRP-1). This could explain why some people with a high viral load are asymptomatic and infectious but unaware they are unwell. It’s like the virus is arriving with it’s own morphine. In theory this might be a successful adaption from the virus’s point of view as it may increase the spread of the disease if infected people wander around able to shed virus for longer.
Despite being fed up with the WuFlu, the efficient perfidy is something to behold (at least to a microbiologist). It’s like a pocketknife.
On the down side, the virus may still be damaging tissues in this painless state, which might explain some of those findings of lung and heart damage even in mild or asymptomatic cases.
There is at least one potentially very nice payoff. The finding from the University of Arizona, may lead to the design of whole new painkillers based on the coronavirus spike that is “better than opioids”. The lead author says he has been contacted by people who had […]
Dr Li-Meng Yan worked in the WHO Coronavirus Reference Lab in Hong Kong. She has just published a detailed paper claiming that the SARS-2 coronavirus was artificially made in a laboratory and appeared on Tucker Carlson’s show today. She also claims it was deliberately spread (though this was slightly ambiguous– listen closely).
We already had enough evidence to know that SARS-Cov2 is a likely bioweapon. (The virus it supposedly evolved from appears to be fake.) This is largely what her paper covers.
Chinese defector virologist Dr Li-Meng Yan publishes report claiming COVID-19 was made in a lab
Phoebe Looms, News.com
Dr Yan had been working at Hong Kong University’s public health laboratory sciences division, a World Health Organisation infectious diseases research centre, when her boss was asked to investigate the outbreak in Wuhan.
Dr Yan claimed her and her team’s scientific findings were suppressed, and they were told only to report cases linked to the Huanan seafood market. After becoming fearful of her safety, she fled China on a flight bound for Los Angeles in late April.
Others in her lab said: “ Dr. Yan’s statement does not accord with the key facts […]
All around the world are dawning headlines wondering if we have founds signs of life on Venus.
Despite the hunt for life on star systems that are lightyears from Earth, it turns out there may be something on the Planet-next-door. “May” being the operative word. A team found phosphine in the atmosphere of Venus and can’t think of any other way it could have got there. Phosphine is considered to be a biomarker. And microbes on Earth would have no trouble making it, though none of them could easily survive on Venus where the atmosphere clouds and rain are nearly pure hot sulphuric acid.*
Scientists find gas linked to life in atmosphere of Venus
Ian Sample, The Guardian
Sara Seager, a planetary scientist on the study at MIT in the US, called the finding “mind-boggling”. She hypothesises a lifecycle for Venusian microbes that rain down, dry out and are swept back up to more temperate altitudes by currents in the atmosphere.
For 2bn years, Venus was temperate and harboured an ocean. But today, a dense carbon dioxide atmosphere blankets a near-waterless surface where temperatures top 450C. The clouds in the sky are hardly inviting, […]
It appears people who wear masks are much less likely to get severe infections
This will make some heads spin.
Child Wearing a a Mask. Author vperemen.com
Not only do masks reduce the odds of getting infected, but if people do get infected while wearing a mask — the severity of Covid is so much milder. With masks on, the odds of getting an asymptomatic infection improve. Masks don’t stop all viral particles but they stop the large droplet clusters, and thus reduce the viral load. If asymptomatic people get some protection (and we still don’t know for sure) it could solve so much.
Consider the two cruise ships where the asymptomatic rate varied from 18 to 81%:
One used masks and one didn’t:
In February, one of the first outbreaks of COVID-19 outside of China occurred on the Diamond Princess cruise ship docked in Yokohama, Japan. Of the 634 people on board who tested positive, about 18 percent of infections were asymptomatic. In March, an Argentinian cruise ship found itself in a similar predicament, but of the 128 people on board who eventually tested positive, 81 percent were asymptomatic— Ghandi et al.
Nations that use […]
Be wary of junk data and junk conclusions
Death data has become a political tool (stretched both up and down by vested interests). We’ve all heard of the motorcyclist who crashed into the Covid tally, and the payments for US docs. We know there’s junk data out there, but the suggestion we only count deaths “from” Covid, and not the deaths “with” Covid is unscientific in the extreme.
Stick with me. We all want WuFlu to be nothing, but scientists and skeptics need to pick their targets carefully. Don’t lose sight of the real scandal and the real solutions. It’s a travesty that people are dying while cheap vitamins and antivirals are being ignored. Let’s fight for Vitamin D, HCQ, Ivermectin, and all the other potentials like Interferon, Bromhexine, Melatonin, steroids, asthma drugs etc etc. But let’s not get distracted by a hopeful fantasy that the true US “death tally” is only 6% of Covid deaths in the US.
There’s an idea out there that only 9,680 people have died of Covid in the US, not 161,392 people. It’s because of this CDC quote:
“For 6% of the deaths, COVID-19 was the only cause mentioned. For deaths with […]
I didn’t think cough syrups even worked against coughs, but one new paper suggests that bromhexine in common cough syrups reduces both Covid-19 rates of ICU and of mortality.
The era of antivirals has come, not that Big Pharma want you to know that cheap out-of-patent drugs might help. But for years we were told that medical science didn’t have an answer to viruses.
Bromhexine was patented in 1961 and is commonly found in OTC pharmacy cough syrups with names like Bisolvon, Robitussin, and Duro-Tuss (Wiki has a long list).
Theoretically Bromhexine sabotages one of our molecules — with the snappy name of TMPRSS2 (which is shorter than saying Transmembrane protease S2). A protease is a fancy pair of molecular scissors, it chops or tweaks the viral spike and if that doesn’t happen, the virus can’t get into the cell (at least not through its favourite path).
The nice thing about an antiviral acting against our molecules, rather than against the virus itself, is that it’s harder for the virus to mutate to get around it. That means it’s less likely the virus can develop resistance. The downside of targeting our own molecules is that it might fritz things up. […]
The first case of a definitive reinfection was reported today
Before we look at whether a cold gives us protection let’s point out we don’t know how well a SARS 2 infection gives us protection.
A 33 year old man in Hong Kong was tested positive nearly five months after his first infection, and with a slightly different variant of the virus, so it’s very likely this was a second infection rather than a resurgence of the first. It hints that Covid may be a bit like the common cold, and our immunity may be partial and temporary which is not good news for the herd immunity idea and the vaccine plan, but it’s only one case. On the plus side, he had a three day fever, cough and sickness in March, but is asymptomatic this time, suggesting that maybe there is enough residual immunity to help him beat the second infection.
There have been other reports of people getting reinfected but none of the previous cases had genetic testing of both infections to show they were different. But 13% of 4,000 doctors who were surveyed in May (even at that early stage) believed that at least one of their […]
Lessons from Coronavirus
Lockdowns and border closures mean many diseases have been prevented
It’s peak season for flu here in Australia and there’s almost no sign of it. As Chris Gillham wrote here back in May, we know lockdowns stop viruses, because flu cases are 85% down. Now he shows that this extends to other diseases too, and Chris has used data from the National Notifiable Diseases Surveillance System to calculate that just shy of 200,000 fewer Australians contracted any of the notifiable diseases in the first seven months of 2020 compared to the first seven months of 2019.
Is some of that disease burden just the price of holiday-makers bringing back diseases from overseas each year?
No one wants to stop the planes returning to the skies, but it begs the question — do we have to accept the onslaught of winter germs every year?
The answer may lie with other things we’ve discovered in the Covid pandemic too — that sick people should stay home from work and school, and that we have a lot of anti-viral tools we can use. Perhaps it’s time that travellers considered taking preemptive anti-virals, which might improve their holidays and also reduce […]
The scandal from the Swamp: Too rich to get a cheap drug?
Poor countries all over the world are using Hydroxychloroquine (HCQ) and it appears to be very useful.
The new HCQTrial suggests that despite the billion dollar budgets and expert staff, people in wealthier countries are dying from Coronavirus at far higher rates than people are in lands where HCQ is being used. And the effect of HCQ apparently holds even after researchers correct for patients being older, heavier, with higher blood pressure, living in high density apartment towers, or with getting tested more.
If word ever gets out that the Politico-Academic-Corporate-Swamp buried useful drugs because they were unprofitable and out of patent, there will be hell to pay.
The HCQTrial was done anonymously by @CovidAnalysis — who say they are PhD researchers, scientists.
You can find our research in journals like Science and Nature. For examples of why we can’t be more specific search for “raoult death threats” or “simone gold fired”. We have little interest in adding to our publication lists, being in the news, or being on TV (we have done all of these things before but feel there are more important things in […]
Do 10,000 extra infections matter?
JoNova — cheaper and faster than a Parliamentary Report — said two months ago that it was baffling that the UK locked everyone down, but kept flying in the virus. Now British MP’s are saying the same.
UPDATE: Given Boris Johnson suddenly changed policy on flights from Spain last week, immediately adding a mandatory quarantine, what’s the bet someone told him this report was coming?
No 10’s ‘inexplicable’ decision to lift quarantine at height of pandemic: MPs’ damning report condemns ‘serious mistake’ that allowed 10,000 infected people into the UK
David Barett, DailyMail
Delaying quarantine measures at the border was a ‘serious mistake’ that allowed 10,000 infected people into the UK accelerated the virus spread, a major report by MPs says.
The cross-party inquiry is highly critical of the Government’s ‘inexplicable’ decision to lift its initial quarantine measures in mid-March, ten days before lockdown.
Experts from the London School of Hygiene and Tropical Medicine calculated that up to 10,000 infected people, largely from Spain, France and Italy, imported the virus into the UK.
Viruses can only survive in people temporarily, so to beat a rogue chemical […]
No wonder the Chinese lockdown a million people with every outbreak. Two thirds of these cases were not hospitalized.
These studies are small and need confirmation, but the medical specialists are asking if it is possible that Covid infections create new cases of heart failure which may trigger problems long after infection?
A startling number of COVID-19 patients suffer lasting heart damage
Fermin Koop, ZME Science
A study from the University Hospital Frankfurt looked at the cardiovascular MRIs of 100 people who had recovered from the coronavirus and compared them with heart images of people who hadn’t been infected.
Most of the patients hadn’t been hospitalized and recovered at home, with symptoms ranging from none to moderate. Two months after recovering from COVID-19, the patients were more likely to have troubling cardiac signs than people in the control group. Up to 78% of them had structural changes to the heart, while 76% had evidence of a biomarker signaling cardiac injury typically found after a heart attack, and 60% had signs of inflammation.
The Puntmann study was based in Germany, and the average age of cases was 49. Troponin is a marker used in standard […]
New research shows that families with teenage children were three times more likely to get Covid (odds of spread , 18%) than families with children under ten (5%). It appears that it’s more dangerous to live with teens than to live with adults (12%). It may be that teens are more likely to be asymptomatic which means people don’t realize they need to isolate from them.
The question of opening primary schools is potentially very different to high schools. Quite possibly puberty affects immune systems in ways that make teens effectively young adults.
Older Kids May Transmit COVID-19 as Much as Adults Do, New Evidence Shows
ScienceAlert
The results also showed up something unexpected, however. When index patients were categorised by age (0–9, 10–19, 20–29, 30–39, 40–49, 50–59, 60–69, 70–79, and >80 years), households with older children (index patients of 10–19 years) had the highest rate of infection spread to household contacts, with 18.6 percent of household contacts later showing the infection.
By contrast, young children (index patients 0–9 years of age) seemed to confer the least amount of spread of the virus, with just 5.3 percent of household contacts contracting the infection, which […]
Welcome to the Era of the Anti-Virals. They’re everywhere.
A legacy of the coronavirus pandemic is the dawn of new ways to stop viruses. Here’s another new (old) one — it’s only a small trial, but if it can stop 4 out of 5 people developing the severe form of the disease it will be a gamechanger. If this gets similar numbers on larger trials, then we still need mass production. But national policies will swing on a dime if a safe drug with this much potential appears.
After Coronavirus we might not be so content to accept the annual seasonal virus scourge.
Postenote: These are preliminary results, not a large trial, but at least it is placebo controlled and randomized.
Breakthrough’ treatment slashes virus death risk: study
by Patrick Galey, MedicalXpress
In a randomised trial of 100 patients admitted to hospital with COVID-19, those who received an inhaled formula of the protein interferon beta were at 79 percent lower risk of developing severe disease compared to those who received a placebo.
They were also more than twice as likely to make a full recovery compared with the control group.
The firm […]
Scott Morrison says eliminating the virus is not viable, despite most states in Australia effectively managing to do that already. See the chart below. Instead he talks of suppression as if it’s viable to ride an exponential curve with a default position of “moonshot”.
At the start of June, Victoria was getting 20 new cases a week. In the last three weeks Victoria has added 3,000 cases.
State premiers are being urged to reject an elimination strategy for coronavirus, with Scott Morrison and leading business groups warning the move would double unemployment and wreck the economy.
The Prime Minister, who has conceded the lockdown of Greater Melbourne was necessary given the size of the outbreaks, warned that any pivot to an elimination strategy would double unemployment.
Suppression sounds like a management plan but means rolling waves of infection and isolation, with outbreaks of chaos and a constant higher level of fear and avoidance. This does not seem like a jobs creation machine.
Would we prefer one lockdown or three?
1. The hospitalization rate means hospitals will be overwhelmed within weeks (see Victoria). Therefore repeat lockdowns are inevitable.
2. It’s hard to protect […]
It’s a molecular monster
The SARS-Cov2 virus can take over and does some pretty cool engineering. (At least in the case of monkey cells.)
The infected cells produce hairy tentacles that poke holes in nearby cells to help spread the virus.
Coronavirus tentacles with small yellow virus particles attached.
So once a virus is inside it can not only hijack the cell to make more viruses (the little yellow prickly balls in the photo) it also forces the cell to make all these hairy tentacles to push the viruses into neighboring cells. Apart from being a neat gee-whiz moment in molecular construction, this is worth knowing because it gives us more targets to aim for. (More moving parts to throw spanners at).
To that end, the team found 87 drugs that are already either FDA approved or in clinical trials that might help. And 7 of them have already shown they can inhibit the virus in both human and monkey cells.
There are some major molecular engineering battles going on
Coronaviruses are larger RNA viruses than most, so that gives the virus more tools to work with. All up we know that there are 27 SARS Cov2 proteins which […]
Good news on the HCQ front
The Henry Ford HCQ study is by no means decisive, but with death rates seemingly halved (sorta, maybe, kinda) — it does show how crazy it is to ban hydroxychloroquine. It also shows it’s low risk, and with all the conflicting studies out there, that there are a lot of ways to stuff things up.
With 10 million cases around the world it seems a bit incongruous that it’s taken so many months to get a trial this basic done with 2,000 patients. When the world only had 10,000 patients in January we already knew that the three drugs that were “fairly effective” were Remdesivir, Chloroquine and Ritonavir. As far back as February 13, the South Koreans were already recommending hydroxychloroquine and telling us the anti-virals should be “started as soon as possible.” They warned that after ten days, doctors “do not have to start antivirals”. South Korea was the experiment that worked — but we ignored it.
Speaking of slow research, the UK hydroxychloroquine trial that was stopped has restarted again as of three days ago. This is a trial to see if HCQ can prevent coronavirus in 40,000 healthcare workers.
[…]
Since Europeans arrived Koalas have been booming and busting
The calls were out this week saying that koalas will be extinct in New South Wales in 30 years. But they didn’t mention that Koalas thrive and multiply so fast that in the right conditions scientists talk of ‘plagues’. On Kangaroo Island last year, there were so many koalas, the South Australian government has been trying to sterilize or relocate thousands of them over the last twenty years. Periodically scientists even discuss whether we have to cull them (the horror!).
They’ve survived twenty megafires in 200 years. They can recover. Ponder that Koalas were only introduced to Kangaroo Island in the 1930’s but by the 1990’s there were 14,000 of them and even though they are considered a tourism asset they are also considered a problem and pest too.
“Nearly everything you have read or heard about koalas, is wrong” — Vic Jurskis
Koalas favorite snack | Photo by pen_ash
Vic Jurskis is a veteran forester and fire expert who studied them for years. He’s written The Great Koala Scam, Green propaganda, junk science government waste and cruelty.
Jurskis estimates that thanks to European settlers there are more […]
Fascinating. Could one shot of radiation calm Covid infected lungs and stop the severe cytokine storm?
In a trial in the US, five very sick Covid patients with a median age of 90 were given a “low dose” (which is not so low) of 1.5 Grey (150 Rad) of Photon beam radiotherapy (in a front and back beam configuration.) It took only 10 – 15 minutes, and four of the five showed “rapid improvement” in 24 hours. Their oxygen levels and alertness improved. They were sent home from hospital 12 days later.
The good thing about this is that apparently most hospitals already have this equipment, so they could start helping people right away (assuming it works, which we don’t know yet).
Radiation isn’t anti-viral, it’s anti-inflammatory
In theory, the shot of radiation is not “killing the virus” but is changing the immune response — and may be able to stop the deadly cascade of the cytokine storm. It calms the immune system in at least three ways (see the chart).
Anti-inflammatory treatment for Covid-19.
The curious thing about this is that it is an old treatment, and an old idea. “Hormesis” is a phenomenon where low grade […]
Just pausing for a moment to say “cheers, New Zealand”.
The last remaining barrier there are closed international borders.
LiveScience Updates
NEW ZEALAND EASES ALMOST ALL CORONAVIRUS RESTRICTIONS AMID NO ACTIVE COVID-19 CASES
— New Zealand has no active cases of the coronavirus, and no new positive cases reported in the past 17 days, according to CNN. For the past 12 days, there are no patients in the hospital receiving treatment for COVID-19 and for the past 40 days, there is no evidence of community transmission, according to CNN. Now, New Zealand is lifting almost all of its coronavirus restrictions, while still encouraging social distancing, keeping borders shut to non-residents and requiring that residents traveling into the country to quarantine for 14 days, according to CNN. New Zealand will be under “alert level 1” rules which means there will be no restrictions on domestic transport and no restrictions on workplaces or services, according to CNN and New Zealand’s government website.
New Zealands daily new cases graphed. Black marks deaths. Wikipedia NZ timeline
New Zealand 1,500 cases and only 22 deaths. The peak of the curve is somewhere around March 30th. The quarantine measures […]
We discussed the inadequacies of the large Lancet study of hydroxychloroquine supposed used on 96,000 Covid patients from 671 hospitals. It was largely useless because it ignored zinc, wasn’t randomized and was mainly used on people who were already very ill, with a terrible 12% death rate. But it is far worse than that and has now been retracted. The number of deaths listed in Australia was higher than the official Australian tally on April 21. The number of Covid cases in Turkey was 80 times higher than official numbers.
All over the world the study spooked doctors and governments (with WHO help) into stopping the use of HCQ in their large trial across in 17 countries .That trial has since been restarted.
The authors have now retracted the paper after Surgisphere refused to transfer the full dataset “due to confidentiality”.
The Guardian investigated the company that came out of nowhere with this enormous dataset which was used in both The Lancet paper and a New England Medical Journal paper. It turned out to be small, with a handful of employees and that include a science fiction writer, an adult content model, and few scientific qualifications. When The Guardian contacted […]
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JoNova A science presenter, writer, speaker & former TV host; author of The Skeptic's Handbook (over 200,000 copies distributed & available in 15 languages).
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