JoNova

A science presenter, writer, speaker & former TV host; author of The Skeptic's Handbook (over 200,000 copies distributed & available in 15 languages).


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Thursday Open Thread

9.9 out of 10 based on 11 ratings

The Death of Democracy. America is Ruled by The Bureaucrats for The Bureaucrats

The Will of the People has been replaced with a Rule by the Bureaucratic Class.

The Bureaucratic class dress themselves in fake charity — to help women and children, minorities, and trees, but these are the lies they tell themselves while they oppress the poor, raze the trees and use sexist, racist policies to line their pockets.

It’s a trend occurring all over the West. But nowhere was it more obvious when the people elected Donald Trump, and the all-knowing Bureaucrats did everything in their power to extinguish the people’s votes.

Washington Examiner, logo.

I have witnessed the death of democracy” says Michael Pack, the man Donald Trump put in charge of the $850 million dollar institution called the U.S. Agency for Global Media which reaches 350 million people each week in 70 languages.  Pack was selected two months after Trump took office, but the Democrats and bureaucrats stalled his appointment for three long years. Pack finally took office in June 2020. His experience exemplifies the control of the faceless Blob of Bureaucracy.

The Death of Democracy

In a sense, we all witnessed it. From the moment Donald Trump was elected president until the day he left office, government officials refused to follow his orders that conflicted with their own views, in spite of their obligation to serve whoever is president. The permanent bureaucracy felt they knew better. After all, they were experts, while the president, in their estimation, was an ignoramus, or worse, unfit for office.

My goal, my only goal, was to return the news services to their legally mandated mission: to report news that is “accurate, objective, and comprehensive” (in the words of the VOA charter, which is U.S. law), and to promote American ideals like democracy and human rights around the world. In this modest, nonpartisan goal, I was doomed from the start. The USAGM permanent bureaucracy was ready to undermine every move of my administration, with the help of their allies in the media, Congress, and the courts, as well as pro bono lawyers. After all, they had been preparing for years while my nomination languished.

The Voice of America ran a repackaged advert for Joe Biden during an election year, with no context, as if it were reporting.

Everyone knew this violated the VOA charter, which is U.S. law that we all are required to uphold, and possibly other campaign and broadcasting laws. When we called this to the VOA’s attention, they took it down, though reluctantly. A week later, we discovered an audio version was still available. As CEO, I decided to launch an investigation to determine who was responsible …

When is the law, not the law. Whenever it suits the bureaucracy:

However, never before I became CEO had there been any consequences for breaking the law. My inquiry was a shock to the system, but I felt I had to uphold the law.

My actions were immediately attacked by the legacy media and by concerned congressmen, all in touch with the people I had fired. They charged that I was interfering with journalists and, once again, trying to turn the VOA into Trump TV.

Lies go unpunished:

One reporter mocked me for saying that the VOA spot was targeted at getting out the Muslim vote in Michigan for Biden, citing how few Urdu speakers there are in Michigan. But the VOA spot was in English, as he well knew, and he also knew that his readers would not know this.

Those who show no respect for taxpayers, voters or the President are promoted to spend more taxpayer dollars to show less respect…

The most senior person responsible was Kelu Chao, then the head of VOA language services. In her case, I merely gave her a verbal reprimand that did not appear in her personnel file. She, too, immediately signed on to a suit against us, alleging a violation of her first amendment rights. Today, she has been rewarded by the Biden administration and is the acting CEO of USAGM, my old position. All others involved in this scandalous misuse of taxpayer funds have been rehired and many promoted.

This is only one of a long list of similar stories. In short, there was no way for me, a Senate-confirmed agency head, to assume authority over this mid-sized agency. The permanent bureaucracy and their allies simply would not permit it. Bad as it was for me, it is so much worse at bigger agencies like the State Department, the Department of Defense, and the intelligence agencies. No matter that Donald Trump was the duly elected president of the United States, federal bureaucrats did not accept that. After all, they knew better how to run the country, so that is what they did. This is tyranny, pure and simple — government by unelected bureaucrats, subverting the will of the majority.

Pack does not think the two most obvious plans to claw back standards or balance can succeed:

The first group says the problem is that Donald Trump did not get enough qualified, experienced, government professionals in key political appointments soon enough. Next time, we need to have a government in waiting, ready to serve. Surely, this is a good idea, but far from sufficient. In my agency of 4,000 people, I could bring in about 10 political appointees. We were outnumbered 400-to-1.

Pretty much all mid and senior level bureaucrats are partisan open political agents.

Even immediate mass firings are unlikely to work:

I highly doubt that this ambitious objective could be achieved, given the size and nature of the modern federal bureaucracy. Government bureaucrats have powerful civil service protections. In eight months, I could not fire a handful of people whom career adjudicators recommended terminating for cause, such as gross mismanagement leading to security lapses. I put them on administrative leave with pay and then started the process of removal. All have been brought back.

Even if the new administration could institute a 30% across-the-board cut, the wrong people would likely be fired. The best at scheming, the most committed ideologues, are the most skilled in surviving reductions in force.

Many of these institutions are beyond saving, and need razing and rebuilding. But when any part of the Bureaucratic Blob is attacked, all parts of the blob fight back.  Cancel one institution and the rest will march in the streets, fearing they will be next.

That doesn’t mean we can’t split the hydra, setting up new institutions in parallel — ones with good people, clear focus, to hire good people. But we need to think carefully about the incentives. All organizations funded by Big Government will always and inevitably become tools to promote Big Government. Perhaps they all need a limited span, an end date. Perhaps Government jobs need a term limit and the Head of a national Health Body shouldn’t be allowed 30 years to build an empire?  Just for starters…

Even better, without hunting for more rules on top of rules, what we all really want is just Real Media. With better mass media, we’d get better politicians and get rid of cheating Department Heads, who served themselves.

Think about how we make that happen. We know it could be a smashing ratings success.

The People still outnumber the Rulers:

So, what can be done? The good news is that about half of Americans know, in their gut, that the government no longer represents the will of the people. They need to rise up and demand an end to this tyranny. We did it before, in 1776. This time, we have a constitution and a rule of law, so we don’t need an armed revolution, but we do need an unarmed one, a peaceful democratic revolution. If a large majority of the people forcefully demand change and reflect this at the ballot box in a clear mandate, then and only then reform can come. Democracy will then return, and we will once again have a government of, for, and by the people. Many gave their lives for this. Now, it is our turn.

People need to stop hoping they can vote for one knight in shining armor to save them.  No one man can defeat the Green-blob, the Bureaucrat Web, — whatever we want to call them, on his own.  The March through the Institutions took decades and a concerted effort by a million footsoldiers. It takes a movement. But a movement is just a few percent of the population who are very very determined and who believe it can be done.

h/t to David E  who also adds this ancient bit of television. Art in it’s purest form. The series Yes Minister never mentioned “Labour” or “Conservative” because it was not about one party versus the other but about the Bureaucrats versus the Politicians.  That’s part of the shell game. The People are taught to see one or other Party as the enemy, when the real adversary rules from behind the curtain.

Errata: Apologies. Michael Peck  corrected to Michael Pack.

9.9 out of 10 based on 65 ratings

Anthony Fauci and a trillion dollars worth of power and corruption…

He’s the highest paid public servant in the US, and has been in the job for decades, and he’s been able to direct nearly a trillion dollars worth of funding. Last year, he helped infect America when it could have been stopped, and this year he’s keeping life saving cheap safe drugs away from patients and their doctors.

Robert F Kennedy Jnr has just launched a sizzling new book called “The Real Anthony Fauci”. I haven’t got a copy yet, but the launch interviews are radioactive. Even worse than the Beagle experiments reported just two weeks ago, are the allegations of experiments on Dominican Orphans, and on sick Americans.

Will The Real Anthony Fauci be able to keep his job?

The Real Anthony Fauci: Bill Gates, Big Pharma, and the Global War on Democracy and Public Health

The Real Anthony Fauci

….

The notes below are from a transcript from an interview of Joseph Mercola and Robert Kennedy.

Here’s what I would say to people. We have to stop this. This is the hill that we all have to die on.

Kennedy claims the patterns repeat decade after decade. Cheap drugs are blocked, while expensive profitable drugs are promoted. Everyone in the chain gets rewarded, except the patients and heretic doctors who get stonewalled and sacked, or potentially very sick.

  • Fauci is the highest-paid federal employee in the U.S., and 68% of his $437,000 a year salary comes from bioweapons research
  • Instead of safeguarding public health, Dr. Anthony Fauci turned the National Institutes of Health into an incubator for pharmaceutical products, and essentially sold the entire country to the drug industry
  • Fauci has had a hand in creating the vaccine gold rush. In 2000, he met with Bill Gates, who asked to partner with the NIH in an agreement to vaccinate the world with a battery of new vaccines. In 2009, this agreement was rebranded as “The Decade of Vaccines,” the objective of which was to implement mandatory vaccinations for every adult and child on the planet by the year 2020.

Philanthropy Capitalism sounds like a cross between the Bankers and the Greens:  Too Big To Fail, and too sacred to criticize.

The cloak of charity is a shield against serious investigation.

“Gates calls what he does philanthropy capitalism, [the idea that] you can use philanthropy to make money. He had a foundation where he has sheltered $50 billion in tax-free money. And, he continues to have absolute control over it. He uses that money to gain control of public health agencies in our country and the World Health Organization.

He’s created a lot of his own [organizations] with Dr. Fauci and a lot of these quasi-governmental agencies that people think are governmental. They’re actually front groups of the pharmaceutical industry like GAVI and SEPI …

He uses this battery and this control of the WHO to set pharmaceutical or medical policy, public health policy around the globe, in a way that maximizes the profits from his stakeholding in these big pharmaceutical companies.

The US government takes most of the risk, does a lot of the advertising, and guarantees the profits:

U.S. taxpayers funded the research while drug companies have made an estimated $100 billion in profits from the shots in a single year, all while having zero liability for injuries and deaths even as people are being coerced into taking them.

It can’t be good to put any one man in charge of such a huge pot of gold:

…between Fauci, Gates and the U.K. Wellcome Trust, they control 63% of the biomedical research on earth through their funding. Over his career, Fauci alone has distributed more than $930 billion in research grants through the NIAID. You could say they control all of it, really, because they also have the capacity to dry up funding to projects they don’t want done.

One one man holds the keys to a vault with so much money, how can it not become a corrupted process? What stops that sole man becoming so influential that many people within a whole branch of science start to perform for him.

This system is like a formalized pal review process in climate science.

“Between 2009 and 2016, about 230 drugs were approved by the FDA, all of which came out of his shop. So, he is an incubator for Pharma.

And here’s what he does: At his lab, he has petri dishes filled with every virus [imaginable], and he has scientists that are messing around with different molecules and different poisons, and they’ll drop those poisons into a petri dish and see if it kills the culture. If it kills the culture, then he has a potential antiviral drug.

The next step is, they give it to rats, and see if it kills the rats. If most of the rats survive, now you have a potential antiviral that may work in humans. Then, he farms it out to a big university. Now the person it goes to at the university is usually a very powerful person. It’s the dean of the medical school, or the chair of one of the departments, and they run the clinical trials, which is extremely lucrative.

So, they will do the Phase 1 trial, and they’ll recruit maybe 100 people for the trial. Fauci gives that principal investigator maybe $20,000 per recruit. The university skims off 50% to 75% of that. So, now, that university is hooked into the system.

Then, if the drug works in Phase 1 and Phase 2, then they have to bring in big groups of people — 10,000 people — and you’re talking about hundreds of millions of dollars. And they have to bring in a pharmaceutical company that now takes control of about half the patent.

Tony Fauci’s agency keeps a share of the patent. For example, they now collect royalties on the Moderna [COVID] vaccine. [The NIAID] gets half the royalties, billions of dollars. The university researcher keeps some of the patent, so he is now permanently attached to Tony Fauci and will do anything he says, and the university itself is getting some of that patent.

If the pile of money is big enough it can silence whole universities…

So, it’s hundreds of millions of dollars that are going to these universities every year, in addition to the grants that he’s giving, and he can cut all that off if somebody at the university does the wrong study.

Keep reading  →

9.7 out of 10 based on 92 ratings

U.S. Military Switches To Swords And Bows To Meet Carbon Neutral Goals

The most surprising thing about the Brandon government is that it hasn’t done this before the Babylon Bee.

US Military Switches to Swords and Bows to meet carbon neutral targets

 

“We have a deadly enemy out there,” announced General “Sparkles” McKenzie, “and it’s called carbon. The problem with modern-day weapons is that they take a lot of carbon to make. But if we get some nice bespoke swords or bows and arrows, that will help us stay carbon neutral, and you can all sleep safe at night.”

There are some problems with the new policy, though. Some military simulations have shown that swords and bows do put the military at a disadvantage against armies that still use irresponsible gunpowder and explosive weapons. “We have a modern weapon for that,” explained McKenzie. “It’s called the hashtag #StopTheBang.

Looks like the US Army will skip the Solar Powered Tank transition proposed by NATO. But swords, bows and arrows are easier to carry on carbon neutral sailing ships. And better for marines using attack-bicycles.

President Xi praised Joe Biden’s foresight and agreed China would switch to carbon neutral weapons by 2070 or straight after Xi is elected Supreme World Leader.

___________

In other news (which is not parody):

Pentagon Spokesman Says Climate Change Is As Big A National Security Threat As China

In response to a question of “which is a bigger threat, the climate or China?” [Pentagon spokesman retired Adm. John Kirby] said, “You’ve heard the secretary talk about the climate as a — a real and existential national security threat . . .  And we considered China as the number one pacing challenge for the department. Both are equally important. Both are — are challenges that the secretary wants the senior leadership at the Pentagon to be focused on, as well as many others, too.

After questioning Kirby was unable to state whether Climate Change or China posed the greater threat.

He appears to be 200 years behind the times. After a hundred thousand years of losing to climate change, living in caves and dying in blizzards, humans defeated climate change with fossil fuels.

 

10 out of 10 based on 47 ratings

Tuesday Open Thread

8.8 out of 10 based on 16 ratings

Green Apologists for China in Glasgow

As David Rose so aptly puts it, China was digging out record amounts of coal and Xi Jinping did not even turn up to Glasgow but green evangelistas were shaming the West and praising China.

Terracotta-army-china

Photo by Christels

Western Environmentalists are being used by the CCP:

‘Useful idiots’ who let China off the hook: Why is there such an apparent lack of concern over their determination to keep burning coal, asks DAVID ROSE

The Daily Mail

Some campaigners even heap praise on China. So why is there such an apparent lack of concern? One answer lies in a book called Hidden Hand: Exposing How The Chinese Communist Party Is Reshaping The World, by Clive Hamilton and Mareike Ohlberg. Serialised in the Mail last year, it argues that China has extended its influence over certain institutions in Britain and other democracies in order to blind them to Beijing’s drive for supremacy.

Xie Zhenhua, China’s chief climate envoy worked for a commission in China accused of torture, detention and forced confessions. Did the Green care?

They include Xie Zhenhua, China’s chief climate envoy. Until 2012, he was a member of the central commission for discipline inspection, which enforces state orthodoxy. According to Human Rights Watch, it has been responsible for illegal detention, torture and forced confessions.

Who knew, Lord Stern was so well connected with China?

Having taught in China since 1998, in 2009 he told a Chinese magazine he had ‘close contacts’ with CCP officials. In 2014, he wrote a paper for the World Economic Forum claiming China was ’emerging as a global leader in climate policy’. In 2016 he claimed China’s emissions ‘may already have peaked’. They hadn’t. The following year, he insisted there was ‘compelling evidence’ China’s coal use had also peaked.

Stern even praised president Xi’s ‘personal commitment to driving climate action’, concluding: ‘The world is looking for a climate champion. In China, it has one.’ But in March he sounded less optimistic, saying it is ‘crucial’ China stops building new coal-fired power plants and stops increasing its emissions by 2025.

Nevertheless, Bob Ward, Stern’s spokesman, told me China was taking ‘significant action’ and the rate of increase in its emissions had slowed enormously.

David Rose discusses how China hosts big conferences for environmental causes which people like Stern, the WWF and other leading crusaders all go to.
Symbol China Map.

The CEO of the Childrens Investment Fund donates millions to group like Extinction Rebellion, but she also is on the board of the Belt and Road International Green Development Coalition run by the CCP. Her name is Kate Hampton and not surprisingly she supports the ‘Chinese leadership’.

It appears often these groups run branches in China and so must sell their souls to the CCP for the “privilege” of being allowed to operate there.  Just as China buys off Big Tech, it buys Big Green.

Perhaps the green blob thinks it can play the game and get access to funds and space in China, but instead the CCP gets access to Western guilt and good-nature to help us cripple ourselves.

Or maybe Green Parasites just want the money.

 

 

 

 

9.8 out of 10 based on 69 ratings

Green Murder — “Don’t let them get away with it” by Ian Plimer

From Ian Plimer: My latest book, Green Murder, will be released on 22nd November 2021. All pre-publication orders I will sign and inscribe. (Put it on your Christmas wishlist, or give it to a friend!)

_______________________________________

Green Murder, Ian Plimer

In this book I charge the greens with murder. They murder humans who are kept in eternal poverty without coal-fired electricity. They support slavery and early deaths of black child miners. They murder forests and their wildlife by clear felling for mining and wind turbines. They murder forests and wildlife with their bushfire policies. They murder economies producing unemployment, hopelessness, collapse of communities, disrupted social cohesion and suicide.

They murder free speech and freedoms and their takeover of the education system has ended up in the murdering of the intellectual and economic future of young people. They terrify children into mental illness with their apocalyptic death cult lies and exaggerations. They try to divide a nation. They are hypocrites and such angry ignorant people should never touch other people’s money.

The greens are guilty of murder. The sentence is life with no parole in a cave in the bush enjoying the benefits of Net Zero.

____

During the time I was writing this book, the coal price rose 100% and LNG price 500%. Don’t tell me that fossil fuels are on the path to extinction. They are needed for survival.

Civilisation advances one coal-fired power station at a time.

If this book has offended you, so be it. Take a daily teaspoon of cement to harden up, broaden your knowledge, reduce your biases and challenge your thinking.

No matter how offended you might be, feelings are not evidence. Green activists are able to get away with murder because they are unchallenged. Certa Bonum Certamen. Don’t let them get away with it.

To pre-order Green Murder

____

Keep reading  →

9.6 out of 10 based on 116 ratings

Well that explains everything: Bankers bullied Australia into Net Zero

Hands Up: It’s Net Zero now or a 1.5% interest rate hike?

So Australia is adopting Net Zero because the Global Financiers, who only want to save the world, would have refused to lend us money without jacking up our interest rates by 1.5%. The banker punishment would have meant a “17% investor exodus”.  Fancy a stock market collapse?

This remarkable admission comes in the modeling released today by the Morrison government. No one is even trying to hide it.

At least we can stop pretending this has anything to do with science or the voters. Just cut out the IPCC and go straight for the BlackRock Temperature Tax, eh?carbon credits, burning dollar note, fiat currency, carbon market.

Note the “penalties” are imposed by global financiers:

Modelling shows real cost of no net-zero carbon emissions

Greg Brown and Geoff Chambers, The Australian

Businesses and households would have faced interest rate hikes of up to 1.5 per cent under expected penalties imposed by global financiers if the government had failed to adopt net zero emissions by 2050, modelling for the Glasgow climate package shows.

The penalty regime would have sparked a 17 per cent investment collapse by the middle of the next decade, cutting 0.9 per cent from gross domestic product and making each Australian more than $650 poorer.

Households would have paid an extra $25bn a year to service home loans, and business and credit card debts.

If only Australia had its own sovereign currency? If only there were competitive money lending institutions out there, somewhere in the whole wide world who were happy to loan us money purely for profit? But no such luck.

Who knew bankers would turn down profits to protect the turtles?

The Elephant in the room. The vested interests rule.

Years ago, I said the corruption starts with the currency, and here it is unmasked. Australians voted for no carbon trading scheme, no carbon tax, and no more climate spending. But long before that we voted for Easy Money and that payday is here.

In theory the modeling was supposed to show how we will be $2,000 richer if we try to change the climate rather than if we leave that to the sun and just make things the customers want instead.

So much for capitalism, competition, and voting for policies.

Net Zero Australia Modeling

Offsets is code for “global emissions trading”.

 

The government revealed it ­received advice from Treasury that there would be a “capital risk premium” of between 100 and 150 basis points if Australia did not adopt a net-zero by 2050 ­target. This would increase borrowing costs on current levels by between $25bn and $38bn, according to economist Saul Eslake.

“It is almost certain that ­Australia would face some form of global response if it did not take on a credible 2050 emissions ­target,” says the government’s analysis of the modelling.

“This could take a variety of forms: increased capital costs for Australian governments, firms and households reflecting increased perceived financial risks; trade action against Australian exports intended to offset any competitive advantage derived from perceived weaker abatement policies; or lower demand for specific Australian products reflecting potential consumer concerns about a perceived lack of action on climate.”

Apparently all bankers really want to help the planet

A giant Spanish Bank once spent €100 b on Earth’s weather, cos they are nice people. Bank of America spent $50 billion to save the world. Citigroup commited $100 billion, Goldman Sachs pledged $750 billion. Banks are just falling all over themselves to help. Deutsche Bank built 70 foot high clock towers of doom, and produced their own climate science reports. Blackrock wanted Australia to shut coal plants faster.

They just worry about the poor and the polar bears, right?

And maybe because Climate change is potentially a $7 Trillion dollar money making venture (for bankers).

Who voted for the Bankers?

The real rulers are the ones who decide the rules and the penalties.

Keep reading  →

9.6 out of 10 based on 118 ratings

Weekend Unthreaded

9.9 out of 10 based on 11 ratings

How many mechanisms do you need? Ivermectin works against Covid in 20 ways

Some claim that we don’t know how ivermectin works, but oh boy we do

Not only do we know how ivermectin protects us, we know many pathways in detail. Ivermectin is useful at every stage of the disease. In the early stages, it reduces the odds of people getting infected, stops the virus multiplying, which reduces the viral load and the spread of the virus to your friends and strangers on the bus.  It helps our cells warn neighboring cells to get ready for a viral attack. It stops the virus getting through the outside wall of our cells, and also stops parts of the virus getting into the headquarters of our cells, the nucleus, where our DNA is.

Ivermectin is also a zinc ionophone which helps zinc cross into cells so zinc can do the good things zinc does…

As the virus tried to assemble itself inside our cells one of the processing tasks involves chopping long proteins into shorter parts. There are many enzymes involved but ivermectin binds to one key one called a Chymotrypsin-like-protease. Ivermectin also conveniently binds to two of the virus proteins as well (called Mpro and PLpro). Basically, ivermectin is the glue no assembly line wants.

In the late stages, ivermectin is an anti-inflammatory drug that reduces the cytokine storm in something like six different ways.

Ivermectin is not just “gum in the works” it’s a kind of Swiss-knife-Velcro-tool — the most sticky, most useful, lock-and-key anti-viral.

With so many  mechanisms of action, it’s difficult for the virus to outsmart ivermectin and mutate around multiple blocks at once. We needed a three-drug-antiviral-cocktail to beat AIDS,  but in terms of resistant mutants arising, Ivermectin is an anti-viral cocktail all by itself. (Obviously used as part of a full medical program.)

Two researchers in Italy, Asiya Kamber Zaidi and Puya Dehgani-Mobaraki, published a paper detailing the 20 different levels of action. It’s quite the marvel, and it came out in May. (Don’t our Chief Health Officers read these papers?)

Ivermectin is the new penicillin

Penecillin changed the world. Imagine if they had banned it?

Click to enlarge:

Zaidi, Mechanisms of Action, Ivermectin, SARS-2, Covid-19

Zaidi, Mechanisms of Action, Ivermectin, SARS-2, Covid-19 (See below for the caption with all the acronyms listed in detail.)

 

As the researchers say, “The probability that an ineffective treatment generated results as positive for the 55 studies to date is estimated to be 1 in 23 trillion (p = 0.000000000000043)”.

Three ways to stop that virus getting in:

Ivermectin binds to the spike (at leucine 91), but it also binds to our ACE2 receptors as well  (at histidine 378). It clogs up the lock-and-key from both ends, and when compared to Remdesivir and hydroxychloroquine, ivermectin bound more strongly to the spike than any of them.

“The free binding energy of the spike protein (open) was higher in Ivermectin (−398.536 kJ/mol) than remdesivir (−232.973 kJ/mol).” (Ewaes 2021)

In this case “higher” means more negative. The higher it is, the more strongly something binds. Negative binding energies mean that binding is spontaneous, and doesn’t need an external energy source.

Ivermectin binds SARS Cov-2 spike. Diagram. Chemistry. Molecule.

From Lehrer et al

 

Ivermectin also binds to TMPRSS2 — it’s not a celebrity molecule like ACE2 — perhaps because someone didn’t think through the PR campaign and call it “Empress2” or something pronounceable  — but it is just as important apparently as ACE2. It seems SARS-2 can’t get into cells which have ACE2 on the surface but don’t also have the TMPRSS2 enzyme there as well (Parmar 2021). Think of TMPRSS2 as a pair of secateurs wandering around the cell surface that need to prune the Covid spike before it can use ACE2 to get into a cell. TMPRSS2 is the not so catchy name for Transmembrane serine protease 2.

Ivermectin also had the highest binding affinity for TMPRSS2. By binding so well to all three — the spike, the ACE2 receptor and the TMPRSS2 secateurs that prune or prime the spike, ivermectin makes it much harder for the virus to get inside a cell.

Protecting the cell nucleus

Once inside a cell, the virus gains access to most resources and tools it needs to produce “baby viruses”, but there’s much more strategy to this war than just a hijacking. Some viral proteins will be sent like trojan gifts to get inside the cell nucleus —  which is effectively the command centre. To get through the locked “gates” into the nucleus, these proteins must get tagged by two labels called importin-α and importin-β   — they mark “the cargo” as something headed for the nucleus. But ivermectin also binds to importin-α, competing with it for spots, and again foiling the virus, clogging up the system and making it hard for SARS2 to send these proteins through the gates.

This is especially important because the nucleus will send out warning signals to other cells — and the viral proteins aim to stop that alarm system being triggered.

Ivermectin helps cells sound the alarm

One of the first cytokines or messengers that a cell-under-siege sends out is called interferon (these names have a kind of Star Trek feeling, don’t they?). Interferon works like an air raid siren. When it reaches other cells, it triggers an array of downstream effects. Cells ramp up their wartime defenses, like for example, making particular enzymes and immune markers they’ll need. But they also slow down the factories and machinery within them that make proteins. These are the same factories the virus wants to hijack and run at high speed to produce its own weapons and baby viruses. In effect, cells are sabotaging their own infrastructure temporarily, to buy time. Some white blood cells called natural killer cells, also respond to interferon. It’s a big deal.

This is such an important advantage for the virus there are at least three SARS proteins that antagonize or work against the interferon signaling system. If the virus can keep infected cells from releasing interferon, it can multiply unhindered for longer. This is all occurring during the early asymptomatic phase. Indeed, the interferon cascade will cause many of the symptoms that tell us we’re coming down with something — like the fever, the aches, and the “flu-like malaise”. Viruses that can slow this process can stop us feeling sick and keep us on our feet — unwittingly shedding baby viruses to infect the guys in the office or the kids at school.

The delay in interferon production not only helps the virus multiply and spread, but also increases the proinflammatory cytokines that cause so much trouble later.

Ivermectin is a multipronged anti-inflammatory

TLR4, toll like receptor 4

TLR4, Toll like receptor 4,   by  David Goodsell

The Covid virus isn’t the only virus that attacks our interferon signally system, though it is a real hallmark of SARS-2, and ultimately the virus wreaks havoc with cytokines on many levels.  Luckily ivermectin also works on several parts of the immune network and mostly the effect appears to be to slow down the key amplifiers that tend to run off the rails in bad Covid infection. Sorry, immunology is acroynm-hell, so bear with me, you’ll get some idea of just how many pathways are affected. For starters, ivermectin slows down the Toll- like-Receptor-4 (TLR4)– these are ancient guards that have been around for a long time. They watch out for signs of spare parts of both bacteria and viruses and even just chemicals that are bad, and have a “pivotal role as an amplifier”. We need our TLR4, we just don’t want it to get “stuck on”.

Strap yourself in, there is so much more. Ivermectin also blocks the NF-κB pathway (Nuclear Factor-κB). It suppresses the Akt/mTOR signalling, which inhibits PAK1 which reduces STAT3 and IL-6.  STAT3 induces C-reactive protein (or CRP), so less STAT3 means less CRP. These are big names in the world of immunology. Your doctor measures your CRP as a sign of inflammation. People interested in living longer talk about the mTOR system  — it’s a is a kind of master controller for the whole cell cycle. Meanwhile IL-6, or interleukin 6 is another messenger that goes “inflammatory” in diseases like diabetes, depression, Alzheimers, and atherosclerosis.  Obviously, it’s better to face Covid without having “raised inflammatory markers” at the start.

Stopping at least one kind of coagulation

Because ivermectin binds to the virus spike at the right point it stops the virus sticking to the CD147 receptors of red blood cells. Each virus has about 100 spikes, so we can imagine how a swarm of viruses would work like a kind of malevolent velcro to agglomerate red blood cells into blobs that can’t pass through blood vessels. There are lot of other ways blood can clot, but ivermectin smooths this form.

The safety tests have already been done

If ivermectin was a new drug discovery, and we read this paper, we might be spooked that ivermectin is so intimately and intricately involved with our core biochemistry. Wise researchers might warn that it may have significant unpredictable side effects and we should research it carefully — but most of those tests have already been done. Thanks to 30 years of mass human use with 3.8 billion doses we are aware there are only a few situations where ivermectin is dangerous, and doctors know all about that. People can still do damage through overdosing. Doses always matter. Ivermectin can bind to our GABA receptors if it can get across the blood brain barrier. In normal healthy people the blood-brain-barrier is intact and and the drug is actively excluded. Doctors should be free to prescribe this “off label”.

No leaky vaccine should be used without an antiviral back up.

Currently, infected people are generating nastier variants because the vaccines are leaky — vaccines reduce the severity (at least for some months) but they don’t stop people shedding and transmitting the virus. We risk generating more deadly forms of Covid — just as we have unwittingly generated more deadly forms of Marek’s disease in domestic chickens by giving them leaky vaccines for the last 50 years.

All of this could stop, and all of this was known months ago.

*Immunology is alphabet soup. If I have vastly oversimplified, I trust commenters will correct me.

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UPDATE: Thanks to Red Edwards– this article has “been retracted”, but is still downloadable here.

The editors objections:

The Editor-in-Chief has retracted this article. Following publication, concerns were raised regarding the methodology and the conclusions of this review article. Postpublication review confirmed that while the review article appropriately describes the mechanism of action of ivermectin, the cited sources do not appear to show that there is clear clinical evidence of the effect of ivermectin for the treatment of SARS-CoV-2. The Editor-in-Chief therefore no longer has confidence in the reliability of this review article. None of the authors agree to this retraction. The online version of this article contains the full text of the retracted article as Supplementary Information.

50 Studies are never enough. The article cites: real-time meta analysis of 52 studies listed at Ivmmeta.com. 2021 [on 2 May 2021]. Available from: https://ivmmeta.com/.

There are 65 studies there now.

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